Publications since:

2009

Bush JO, Soriano P.  Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.

Genes Dev. 2009 23, 1586-1599.

Olson, L.E. and Soriano, P. (2009).  Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis.  Developmental Cell, 16, 303-313.

2008

Schmahl J, Rizzolo K, Soriano P. The PDGF signaling pathway controls multiple steroid producing lineages. Genes and Development, 22:3255-3267.

Qiu, R., Wang, X., Davy, A., Wu, C., Murai, K., Zhang, H., Flanagan, J.G., Soriano, P., and Lu, Q. (2008).  Regulation of neural progenitor cell state by ephrin-B.  J. Cell Biol., 181, 973-983.  Abstract

2007

Davy, A. and Soriano, P. (2007).  Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development.  Dev Biol., 308, 182-193. Abstract 

Raymond, C.S. and Soriano, P. (2007).  High-Efficiency FLP and PhiC31 Site-Specific Recombination in Mammalian Cells.  PLoS ONE, 2, e162.  Abstract

Schmahl, J., Raymond, C.S., Soriano, P.  (2007).  PDGF signaling specificity is mediated through multiple immediate early genes.  Nature Genetics, 39, 52-60. Abstract

2006

Davy, A., Bush, J.O., Soriano, P. (2006).  Inhibition of Gap Junction Communication at Ectopic Eph/ephrin Boundaries Underlies Craniofrontonasal Syndrome.  PLoS Bio., 4, 1763-1776. Abstract 

Raymond, C.S. and Soriano, P.  (2006).  Engineering Mutations: Deconstructing the mouse gene by gene.  Developmental Dyn., 235, 2424-36.  Abstract 

Hoch, R.V. and Soriano, P. (2006).  Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.  Development, 133, 663-673. Abstract 

Nord A.S., Chang P.J., Conklin B.R., Cox A.V., Harper C.A., Hicks G.G., Huang C.C., Johns S.J., Kawamoto M., Liu S., Meng E.C., Morris J.H., Rossant J., Ruiz P., Skarnes W.C., Soriano P., Stanford W.L., Stryke D., von Melchner H., Wurst W., Yamamura K., Young S.G., Babbitt P.C., Ferrin T.E. (2006).  The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.  Nucleic Acids Res., 34, D642-648. Abstract 

2005

Davy, A. and Soriano, P. (2005).  Ephrin signaling in vivo: look both ways.  Developmental Dyn., 232, 1-10. Abstract 

Xu, X., Bringas Jr., P., Soriano, P. and Chai, Y. (2005).  PDGFR-a signaling is critical for tooth cusp and palate morphogenesis.  Developmental Dyn., 232, 75-84. Abstract 

2004

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B. (2004). The knockout mouse project.  Nature Genetics, 36, 921-4. Abstract 

Ding, H., Wu, X., Boström, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G.Y., Soriano, P., Betsholtz, C., Hart, T.C., Marazita, M.L., Field, L.L., Tam, P.P.L., and Nagy, A. (2004).  A specific requirement of PDGF-C in palate formation and PDGFR-a signaling.  Nature Genetics, 36, 1111-6. Abstract  :  Supplementary Information
Aubin, J., Davy, A. and Soriano, P. (2004).  In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis.  Genes Dev., 18, 1482-1494. Abstract 

Skarnes, W.C., von Melchner, H., Wurst, W., Hicks, G., Nord, A.S., Cox, T., Young, S.G., Ruiz, P., Soriano, P., Tessier-Lavigne, M., Conklin, B.R., Stanford, W.L., and Rossant, J. (2004).  A public gene trap resource for mouse functional genomics.  Nature Genetics, 36, 543-544. Abstract 

Chen, W.V., Delrow, J., Corrin, P.D., Frazier, J.P., and Soriano, P. (2004). Identification and Validation of PDGF transcriptional targets by microarray-coupled gene trap mutagenesis. Nature Genetics, 36, 304-312. Abstract  :  Supplementary Information

Davy, A., Aubin, J. and Soriano, P. (2004). Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev., 18, 572-83. Abstract 

2003

Tallquist, M.D., French, W.J. and Soriano, P. (2003).  Additive effects of PDGF receptor b signaling pathways in vascular smooth muscle cell development.  PLoS Biology, 1, 288-299. Full Text 

Chen, W.V., and Soriano, P. (2003).  Gene trap mutagenesis in embryonic stem cells. In Differentiation of Embryonic Stem Cells (P.M. Wassarman and G. M. Keller, eds.), Methods in Enzymology, 365, 367-386. Abstract 

Awatramani, R., Soriano, P., Rodriguez, C., Mai, J.J. and Dymecki, S.M. (2003).  Cryptic boundaries in roof plate and choroid plexus revealed by
intersectional gene activation.  Nature Genetics, 35, 70-75. Abstract 

Hoch, R.V., and Soriano, P. (2003).  PDGF roles in animal development. Development, 130, 4769-4784. Abstract

Tallquist, M.D. and Soriano, P. (2003). Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development. 130, 507-518. Abstract 

Hamilton, T.G., Klinghoffer, R.A., Corrin, P.D., and Soriano, P. (2003). Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol., 23, 4013-25. Abstract 

2002

Hildebrand, J.D. and Soriano, P. (2002). Overlapping and unique functions of CtBP1 and CtBP2 during mouse embryonic development. Mol. Cell. Biol., 22, 5296-5307. Abstract 

Klinghoffer, R. A., Hamilton, T. G., Hoch, R., and Soriano, P. (2002). An allelic series at the PDGFaR locus indicates unequal contributions of distinct signaling pathways during development. Developmental Cell, 2, 103-113. Abstract

Komada, M. and Soriano, P. (2002). bIV-Spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol., 156, 337-348. Abstract 

2001

Nadeau, J.H., Balling, R., Barsch, G., Beier, D., Brown, S.D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L., Hicks, G., de Angelis, M.H., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A., Rinchik, E.M., Rossant, J., Russell, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W., and Zimmer, A. (2001). Sequence interpretation. Functional annotation of mouse genome sequences. Science, 291, 1251-1255. Abstract 

Klinghoffer, R.A., Mueting-Nelsen-P.F., Faerman, A, Shani, M. and Soriano, P. (2001). The two PDGFRs display conserved signaling in vivo despite divergent embryological functions. Molecular Cell, 7, 343-354. Abstract 

Medico, E., Gambarotta, G., Gentile, A., Comoglio, P.M., and Soriano, P. (2001). Identification of HGF target genes by a novel genome-wide functional screening. Nature Biotech. 19, 579-582. Abstract 

Awatramani, R., Soriano, P., Mai, J.J., and Dymecki, S. (2001). A FLP indicator mouse expressing alkaline phosphatase from the ROSA26 Locus. Nature Genetics, 29, 257-259. Abstract 

2000

Tallquist, M.D. and Soriano, P. (2000). Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic versus extra-embryonic gene function. Genesis, 26, 113-115. Abstract 

Jiang, X., Rowitch, D.H., Soriano, P., McMahon, A.P., and Sucov, H.M. (2000). Fate of the mammalian cardiac neural crest. Development, 127, 1607-1616. Abstract 

Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D.H., Soriano, P., McMahon, A.P., and Sucov, H. (2000). Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development, 127, 1671-1679. Abstract 

Klesert, T.R., Cho, D.H., Clark, J.I., Maylie, J., Adelman, J., Snider, L., Yuen, E.C., Soriano, P., and Tapscott, S.J. (2000). Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nature Genetics, 25, 105-109. Abstract 

Li, X., Ponten, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Backström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C-H., Alitalo, K., Östman, A. and Eriksson, U. (2000) PDGF-C is a new protease-activated ligand for the PDGF a-receptor. Nature Cell Biol., 2, 302-309. Abstract 

Komada, M., McLean, D.J., Griswold, M.D., Russell, L.D., and Soriano, P. (2000). E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes Dev., 14, 1332-1342. Abstract 

Tallquist, M.D., Weismann, K., Hellström, M., and Soriano, P. (2000). Early myotome specification regulates PDGFA expression and axial skeleton development. Development, 127, 5059-5070. Abstract 

Farley, F.W., Soriano, P., Steffen, L., and Dymecki, S.M. (2000). Widespread recombinase expression using FLPeR (Flipper) Mice. Genesis, 28, 106-110. Abstract 

Tallquist, M.D., Klinghoffer, R.A., Heuchel, R., Mueting-Nelsen, P.F., Corrin, P.D., Heldin, C-H., Johnson, R.J., and Soriano, P. (2000). Retention of PDGFR b function in mice in the absence of phosphatidylinositol-3' kinase and phospholipase C g signaling pathways. Genes Dev., 14, 3179-3190. Abstract 

1999

Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genetics, 21, 70-71. Abstract

Lanier, L.M., Gates, M., Witke, W., Menzies, A.S., Wehman, A.M., Macklis, J., Kwiatkowski, D., Soriano, P., and Gertler, F.B. (1999). Requirement of Mena in neurulation and commissure formation. Neuron 22, 313-325. Abstract 

Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S-H, Mobley, W.C., Soriano, P., and Brodsky, F.M. (1999). EGF receptor signaling stimulates Src kinase phosphorylation of Clathrin influencing Clathrin redistribution and EGF uptake. Cell 96, 677-687. Abstract 

Klinghoffer, R., Sachsenmaier, C., Cooper, J.A., and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-2471. Abstract 

Komada, M. and Soriano, P. (1999). Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 13, 1475-1485. Abstract 

Ohlsson, R., Falck, P., Hellström, M., Lindahl, P., Bostrom, H., Franklin, G., Ahrlund-Richter, L., Pollard, J., Soriano, P., and Betsholtz, C. (1999). PDGF-B regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev. Biol. 212, 124-136. Abstract 

Heuchel, R., Berg, A., Tallquist, M., Ahlen, K., Reed, R.K., Rubin, K., Claesson-Welsh, L., Heldin, C.H., and Soriano, P. (1999). Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3´-kinase signaling. Proc. Natl. Acad. Sci. USA, 96, 11410-11415. Abstract 

Hildebrand, J.D., and Soriano, P. (1999). Shroom, a PDZ domain-containing actin-binding protein, is required for neural-tube morphogenesis in mice. Cell, 99, 485-497. Abstract 

Andrews, A., Balciunaite, E., Leong, F.L., Tallquist, M., Soriano, P., Refojo, M. and Kazlauskas, A. (1999) Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 40, 2683-2689. Abstract 

Davy, A., Gale, N.W., Murray, E.W., Klinghoffer, R.A., Soriano, P., Feuerstein, C. and Robbins, S.M. (1999). Compartmentalized signaling by GPI-anchored Ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 13, 3125-3135. Abstract 

Tallquist, M.D., Soriano, P., and Klinghoffer, R.A. (1999). Growth factor signaling pathways in vascular development. Oncogene, 18, 7917-7932. Abstract 

1998

Cohen, N.R., Taylor, J.S.H., Scott, L.B., Guillery, R.W., Soriano, P., and Furley, A. (1998) Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Current Biol., 8, 26-33. Abstract

Foley, K.P., McArthur, G.A., Queva, C., Hurlin, P.J., Soriano, P., and Eisenman, R.N. (1998). Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J., 17, 774-785. Abstract

Crosby, J.R., Seifert, R.A., Soriano P., and Bowen-Pope, D.F. (1998). Chimaeric analysis reveals role of PDGF receptors in all muscle lineages. Nature Genetics 18, 385-388. Abstract

Fransen, E., D'Hooge, R., Van Camp, G., Verhoye, M., Sijbers, J., Reyniers, E., Soriano, P., Kamiguchi, H., Willemsen, R., Koekkoek, S.K.E., De Zeeuw, C.I., De Deyn, P.P., Van der Linden, A., Lemmon, V., Kooy, R.F. and Willems, P.J. (1998). L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Hum. Mol. Genet. 6, 999-1009. Abstract

Lindahl, P., Hellström, M., Kalén, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P. and Betsholtz, C. (1998). Paracrine PDGF-B/PDGF-Rb signaling controls mesangial cell development in kidney glomeruli. Development 125, 3313-3322. Abstract

Gallagher, E., Howell, B.W., Soriano, P., Cooper, J.A., and Hawkes, R. (1998). Cerebellar abnormalities in the disabled (mdab1-1) mouse. J. Comp. Neurol. 402, 238-251. Abstract

1997

Zambrowicz, B.P., Imamoto, A., Fiering, S., Herzenberg, L.A., Kerr, W.G., and Soriano, P. (1997). Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of b galactosidase in mouse embryos and hematopoietic cells. Proc. Natl. Acad. Sci. USA, 94, 3789-3794. Abstract

Chan, V.W.F., Meng, F., Soriano, P., DeFranco, A.L., Lowell, C.A. (1997). Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity, 7, 69-81. Abstract

Soriano, P. (1997). The PDGF a Receptor is required for neural crest cell development and for normal patterning of the somites. Development, 124, 2691-2700. Abstract

Howell, B.W., Hawkes, R., Soriano, P., and Cooper, J.A. (1997). Neuronal position in the developing brain is regulated by mouse disabled-1. Nature, 389, 733-737. Abstract

Friedrich, G.A., Hildebrand, J.D., and Soriano, P. (1997). The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev. Biol., 192, 364-374. Abstract

1996

Lowell, C.A., and Soriano, P. (1996). Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev., 10, 1845-1857. Abstract

Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., and Soriano, P. (1996). Mena, a relative of Vasp and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell, 87, 227-239. Abstract

Lowell, C.A., Niwa, M., Soriano, P., and Varmus, H.E. (1996). Deficiency of Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood, 87, 1780-1792. Abstract

1995

Soriano, P. (1995). Gene targeting in ES cells. Annual Review Neuro. 18, 1-18. Abstract

MacGregor, G.R., Zambrowicz, B.P., and Soriano, P. (1995). Tissue non-specific alkaline phosphatase is expressed in both embryonic and extra-embryonic lineages during mouse development but is not required for migration of mouse primordial germ cells. Development, 121, 1487-1496. Abstract

Thomas, S.M., Soriano, P., and Imamoto, A. (1995). Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature, 376, 267-271. Abstract

1994

Guy, C.T., Muthuswamy, S.K., Cardiff, R.D., Soriano, P., and Muller, W.J. (1994). Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev.,8, 23-32. Abstract

Imamoto, A., Soriano, P., and Stein, P.L. (1994). Genetics of signal transduction: tales from the mouse. Curr. Opin. Genet. Dev., 4, 40-46. Abstract

Kiefer, F., Anhauser, I., Soriano, P., Aguzzi, A., Courtneidge, S. A., and Wagner, E. F. (1994). Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases. Current Biology,4, 100-109. Abstract

Lowell, C.A., Soriano, P., and Varmus, H. E. (1994). Functional overlap in the src-gene family: Inactivation of hck and fgr impairs natural immunity. Genes Dev., 8, 387-398. Abstract

Ignelzi Jr., M. A., Miller, D. R., Soriano, P., and Maness, P. F. (1994). Impaired neurite outgrowth of src minus neurons on the cell adhesion molecule L1. Neuron, 12, 873-884. Abstract

Soriano, P. (1994). Abnormal kidney development and hematological disorders in PDGF b receptor mutant mice. Genes Dev., 8, 1888-1896. Abstract

Stein, P.L., Vogel, H., and Soriano, P. (1994). Combined deficiencies of src, fyn, and yes tyrosine kinases in mutant mice. Genes Dev., 8, 1999-2007. Abstract

Chen, Z., Friedrich, G. A., and Soriano, P. (1994). Transcriptional Enhancer Factor-1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev., 8, 2293-2301. Abstract

Beggs, H.E., Soriano, P., Maness, P.F. (1994). N-CAM-dependent neurite outgrowth is inhibited in neurons from Fyn- mice. J. Cell Biol., 127, 825-833. Abstract

Zhuang, Y., Soriano, P., and Weintraub, H. (1994). The helix-loop-helix gene E2A is required for B-Cell formation. Cell, 79, 875-884. Abstract

1993

Boyce, B.F., Chen, H., Soriano, P., and Mundy, G.R. (1993) Histomorphometric and immunocytochemical studies of Src-related osteopetrosis. Bone, 14, 335-340. Abstract

Lowe, C., Yoneda, T., Boyce, B. F., Mundy, G. R., and Soriano, P. (1993). Osteopetrosis in src deficient mice is due to an autonomous defect of osteoclasts. Proc. Natl. Acad. Sci. USA, 90, 4485-4489. Abstract

Thomas, J. E., Aguzzi, A., Soriano, P., Wagner, E. F., and Brugge, J. S. (1993). Induction of tumor formation and cell transformation by Polyoma middle T antigen in the absence of src. Oncogene, 8, 2521-2529. Abstract

Imamoto, A., and Soriano, P. (1993). Disruption of the csk gene, encoding a negative regulator of src family kinases, leads to neural tube defects and embryonic lethality in mice. Cell, 73, 1117-1124. Abstract

Grompe, M., Al-Dhalimy, M., Finegold, M., Ou, C. N., Burlingame, T., Kennaway, N. G., and Soriano, P. (1993) Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev., 7, 2298-2307. Abstract

Friedrich, G., and Soriano, P. (1993). Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells. In Guide to Techniques in Mouse Development (P.M. Wassarman and M.L. DePamphilis, eds.), Methods in Enzymology 225, 681-701. Abstract

1992

Stein, P. L., Lee, H., Rich, S., and Soriano, P. (1992). pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70, 741-750. Abstract

Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P., and Mundy, G. R. (1992). Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone. J Clin. Invest., 90, 1622-1627. Abstract

Giese, K. P., Martini, R., Lemke, , G., Soriano, P., and Schachner, M. (1992). Disruption of the P0 gene in mice leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell, 71, 565-576. Abstract

Grant, S. G. N., O'Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P., and Kandel, E. R. (1992). Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258, 1903-1910. Abstract

O'Dell, T.J., Grant, S.G.N., Karl, K., Soriano, P., and Kandel, E.R. (1992). Pharmacological and genetic approaches to the analysis of tyrosine kinase function in long term potentiation. Cold Spring Harbor Symp. Quant. Biol., 57, 517-526. Abstract

1991

Soriano, P., Friedrich, G., and Lawinger, P. (1991). Promoter interactions in retroviral vectors introduced into fibroblasts and embryonic stem cells. J. Virol. 65, 2314-2319. Abstract

Friedrich, G., and Soriano, P. (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5, 1513-1523. Abstract

Soriano, P., Montgomery, C., Geske, R., and Bradley, A. (1991).Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702. Abstract

Thomas, J., Soriano, P., and Brugge, J. S. (1991). Phosphorylation of c-src on tyrosine 527 by another protein tyrosine kinase. Science 254, 568-571. Abstract