Training Faculty for Developmental and Stem Cell Biology (DSCB)

1. Program Directors:
   

2. Margaret Baron, M.D., Ph.D., and Robert Krauss, Ph.D.
   

3. Steering Committee:
   

4. James Bieker, Ph.D., Ross Cagan, Ph.D., Kevin Kelley, Ph.D., Ihor Lemischka, Ph.D., Robert F. Margolskee, M.D. Ph.D., Marek Mlodzik, Ph.D., Hans Snoeck, M.D. Ph.D., Daniel C. Weinstein, Ph.D.
   

Training Faculty

1. Basic Science Research
   

2. •Stuart A. Aaronson, M.D., Professor, Department of Oncological Sciences
   Molecular genetics of cancers.
   

3. •Penny A. Asbell, M.D., Professor, Department of Ophthalmology
   

4. •Margaret H. Baron, M.D., Ph.D., Professor, Department of Medicine (Hematology and Medical Oncology)
   Molecular regulation of mammalian stem cell differentiation and development; development of the mammalian cardiovascular system; erythropoiesis
   

5. •Andrew D. Bergemann, Ph.D., Assistant Professor, Department of Pathology
   Axon guidance and developmental neurobiology
   

6. •Audrey Bernstein, Ph.D., Assistant Professor, Department of Ophthalmology
   Mechanisms that promote regenerative repair over fibrotic wound healing specifically investigating the regulation of TGFb, extracellular matrix compositon, and proteases in an effort to control the fibrotic response.
   

7. •James J. Bieker, Ph.D., Professor, Department of Developmental and Regenerative Biology
   Transcriptional regulation of red cell specific gene expression.
   

8. •Erwin P. Bottinger, M.D., Professor, Department of Medicine
   TGF-B/Smad signaling networks and transcriptomics/genomics; gene expression; genomics; proteomics; microarray; systems biology; nephrology; hypertension; diabetes mellitus; pathobiology.
   

9. •Ross Cagan, Ph.D., Professor, Department of Developmental and Regenerative Biology
   Drosophila disease and development models, cancer models including breast, lung, and thyroid, diabetes models including heart dysfunction, epithelial development including retinal patterning.
   

10. •Chenleng Cai, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
    Interested in deciphering the transcriptional signaling cascades controlling the early induction and development of mammalian heart. Uncovering the transcriptional signaling cascades underlying the early induction and development of heart has important implications for cardiac regenerative biology.
    

11. •Shu-Hsia Chen, Ph.D., Associate Professor, Department of Gene and Cell Medicine
    Cancer Immunology, immune modulated cancer therapy.
    

12. •Paul S. Frenette, M.D., Associate Professor, Department of Medicine
    Adhesion mechanisms regulating hematopoiesis and the pathophysiology of sickle cell disease.
    

13. •Isabelle M. Germano, M.D., Professor, Department of Neurosurgery
    MOlecular biology and translational research of primary brain tumor, embryonic stem cell differentiation and gene therapy for brain tumors.
    

14. •Saghi Ghaffari, M.D., Ph.D., Assistant Professor, Department of Gene and Cell Medicine
    Molecular Mechanisms of Regulation of Hematopoietic Stem and Progenitor Cell Fate.
    

15. •Jeanne P. Hirsch, Ph.D., Associate Professor, Department of Pharmacology and Systems Therapeutics
    Signal transduction pathways mediated by heterotrimeric G proteins in the yeast Saccharomyces cerevisiae.
    

16. •Luis Isola, M.D., Professor, Department of Medicine (Hematology and Medical Oncology)
    

17. •Kevin Kelley, Ph.D., Professor, Department of Developmental and Regenerative Biology
    Creation of animal models for the study of gene regulation, gene function and human diseases.
    

18. •Robert S. Krauss, Ph.D., Associate Professor, Department of Developmental and Regenerative Biology
    Cell Adhesion and Signal Transduction in Pattern Formation and Cell Differentiation During Development.
    

19. •Jeffrey T. Laitman, Ph.D., Professor , Center for Anatomy and Functional Morphology
    Development and evolution of the mammalian aerodigestive system; vocal tract development; evolutionary origins of speech.
    

20. •Ihor Lemischka, Ph.D., Professor, Department of Gene and Cell Medicine
    

21. •Xiajun (John) Li, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
    Acquisition and maintenance of DNA methylation genomic imprints. A maternal-zygotic effect gene in mouse. LIN-12/Notch signaling in cardiovascular development. Maintenance and differentiation of embryonic stem cells.
    

22. •Reigh-Yi Lin, Ph.D., Assistant Professor, Department of Medicine
    Developmental Biology, Stem Cell, Thyroid.
    

23. •Zhongmin Ma, Ph.D., Assistant Professor, Department of Geriatrics and Adult Development
    Phospholipid signaling in pancreatic beta-cell function, apoptosis, and regeneration; cell membrane homeostasis and cell cycle checkpoint regulation; molecular pathogenesis of infantile neuroaxonal dystrophy.
    

24. •Robert F. Margolskee, M.D., Ph.D., Professor, Department of Neuroscience
    Molecular, transgenic and structural techniques to study peripheral and central mechanisms of taste transduction and coding to determine how these pathways regulate gustatory behaviors in vivo
    

25. •Sandra K. Masur, Ph.D., Professor, Department of Ophthalmology
    Cell-cell and cell-matrix interaction during wound healing.
    

26. •Marek Mlodzik, Ph.D., Professor, Department of Developmental and Regenerative Biology
    Cell-cell interactions during epithelial and nervous system patterning: planar polarity establishment
    

27. •Kateri A. Moore, DVM, Associate Professor, Department of Gene and Cell Medicine
    Stem Cells/Microenvironment/Stem Cell NIche, Cell, Developmental, Molecular regulation of hematopoietic stem cell self renewal and differentiation, molecular interaction of stem cells and microenvironmental elements, ie. the stem cell niche regulation of stem cells.
    

28. •Cathie Pfleger, Ph.D., Assistant Professor, Department of Oncological Sciences
    How the processes of growth and proliferation are regulated and how loss of that regulation leads to cancer, with a special emphasis on regulation by the ubiquitin pathway.
    

29. •Michael Rendl, M.D., Assistant Professor, Department of Developmental and Regenerative Biology
    Cell fate specification of stem cell niche cells during hair morphogenesis; stem cell activation by dermal papilla niche cells during hair formation and regeneration.
    

30. •Kirsten Sadler-Edepli, Ph.D., Assistant Professor, Department of Developmental and Regenerative Biology
    Using zebrafish to understand liver development, regeneration and disease.
    

31. •Takeshi Sakurai, M.D. Ph.D., Assistant Professor, Department of Psychiatry
    My research interest has been how nervous system develops at the molecular level, i.e., molecular mechanisms of wiring and synapse formation, and how alterations in these processes lead to neurological and pscyhiatric disorders.
    

32. •Hans-Willem Snoeck, M.D., Ph.D., Associate Professor, Department of Gene and Cell Medicine
    Stem cell biology; immunology; gene therapy; hematopoiesis.
    

33. •Sergei Y. Sokol, Ph.D., Professor, Department of Developmental and Regenerative Biology
    Cell polarity in vertebrate development, neural development, axis specification, Wnt signaling, morphogenetic movements, asymmetric cell division.
    

34. •Philippe M. Soriano, Professor, Department of Developmental and Regenerative Biology
    Our laboratory focuses on the role of specific growth factor signaling pathways (PDGF and FGF) in mouse development, using targeted and gene trap mutagenesis. Another area of research is the regulation of neural crest development by ephrin signaling.
    

35. •David W. Sternberg, M.D., Ph.D., Assistant Professor, Department of Medicine (Hematology and Medical Oncology)
    Aberrant protein tyrosine kinase signaling in cancer; translational control of gene expression in malignancy; mechanisms of resistance to protein tyrosine kinase inhibitors.
    

36. •Frederick J. Suchy, M.D., Professor , Department of Pediatrics
    Basolateral and canalicular transporters for bile acids and other organic anions.
    

37. •Herb B. (Hui Bin) Sun, Ph.D., Assistant Professor, Department of Orthopaedics
    Gene regulation and signal transduction of joint tissue homeostasis; mechanotransduction pathway and its potential use for disease prevention and treatment; effects of chemo-factors and mechano-factors on MSC renewal, commitment, and differentiation; role of MSCs in wound healing and tissue engineering.
    

38. •Paul M. Wassarman, Ph.D., Professor , Department of Developmental and Regenerative Biology
    Mechanisms of fertilization in mammals.
    

39. •Jose M. Wolosin, Ph.D., Professor, Department of Ophthalmology
    

40. •Qin Yu, Ph.D., Assistant Professor , Department of Oncological Sciences
    Effects of tumor microenvironment on tumor invasion/metastasis and tumor angiogenesis; Identification of targets and agents for therapeutic intervention of human glioma, ovarian cancer, melanoma, and breast cancer.
    

41. Clinical Research
    

42. •Stuart A. Aaronson, M.D., Professor, Department of Oncological Sciences
    Molecular genetics of cancers.
    

43. •Ross Cagan, Ph.D., Professor, Department of Developmental and Regenerative Biology
    Drosophila disease and development models, cancer models including breast, lung, and thyroid, diabetes models including heart dysfunction, epithelial development including retinal patterning.
    

44. •Isabelle M. Germano, M.D., Professor, Department of Neurosurgery
    Molecular biology and translational research of primary brain tumor, embryonic stem cell differentiation and gene therapy for brain tumors.
    

45. •Takeshi Sakurai, M.D. Ph.D., Assistant Professor, Department of Psychiatry
    My research interest has been how nervous system develops at the molecular level, i.e., molecular mechanisms of wiring and synapse formation, and how alterations in these processes lead to neurological and pscyhiatric disorders.
    

© 2008 Mount Sinai Medical Center